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 SAAM II
Pharmacokinetic Case Studies
[34K MSWord]
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Cadralazine kinetics [425K
PDF]
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How to create a one-compartment
model
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How
to write equations for the noncompartmental parameters
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How
to obtain initial parameter estimates
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How
to fit your model to the data
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How
to use Notes to keep track of your modeling work
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How
to define alternative one-compartment model
parameterizations
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Epsilon aminocaproic Acid (EACA)
Pharmacokinetics/-Pharmacodynamics
[261K
PDF]
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How to use a biophase
compartment to link PK and PD
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How
to create an Emax PD Model
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How
to use SAAM II Bayesian
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Gentamicin kinetics – a simulation case study
[228K PDF]
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How to use simulations to
examine toxicity differences between patients
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How
to use simulations to analyze the impact of different
dosing regimens
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How
do flip-flop kinetics result from slow gentamicin
distribution
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How
to use the Duplicate command
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How
to incorporate Michaelis-Menten kinetics in a transfer
function
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Hydromorphone kinetics
[643K
PDF]
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How to obtain initial parameter
estimates for a two-compartment model
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How
to write the equations for the noncompartmental
parameters
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How
to evaluate the area under the curve (AUC)
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How
to investigate different two compartment model
structures (identifiability of the two compartment
model)
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Inulin kinetics
[618K
PDF]
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How to create a two-compartment
model
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How
to obtain initial parameter estimates
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How
to evaluate the “Fit”
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How
to add a third compartment
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How
to analyze plasma and urine data simultaneously
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How
to use Change Conditions
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How
to evaluate the pharmacokinetic parameters
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N-Acetylprocainamide (NAPA) kinetics
[287K
PDF]
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Theophylline Kinetics Following a Short
Intravenous Infusion
[458K
PDF]
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How to create a two-compartment
model
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How
to obtain initial parameter estimates
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How
to evaluate the “Fit”
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How
to add a third compartment
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How
to compare the results of two different models
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How
to write some noncompartmental parameters
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Oral Theophylline Kinetics
[657K
PDF]
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How to create a one-compartment
model with absorption
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How
to obtain initial parameter estimates
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How
to write the equations for the noncompartmental
parameters
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How
to identify two solutions that exist for this model
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How
to use a priori knowledge
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N-Acetylprocainamide (NAPA) Kinetics in a
Hemodialysis Patient
[958K PDF]
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How to analyze data generated
from studies in functionally anephric patients that are
receiving hemodialysis.
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How
to use the transfer attributes box and the sample
attributes box, as well as the equations window, to add
equations to the model.
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How
to use the change conditions tool to initiate and
terminate dialysis clearance.
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How
to create a forcing function using the input tool to
model hemodialysis-associated alterations in model
parameters.
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The
importance of using the recovery method to calculate
hemodialysis clearance.
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How
to incorporate “venous” plasma concentrations in a
hemodialysis model to estimate effective dialyzer blood
flow and the fallacy of using plasma flow to calculate
hemodialysis clearance by the A-V difference method.
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Data Files
[3K ZIP]
In 2004, the SAAM
Institute in collaboration with Dr. Ron Sawchuk at the
University of Minnesota sponsored a workshop in
pharmacokinetics. Dr. Sawchuk, a long-time SAAM II user, had
developed a series of case studies which he used in his
courses. Three of these he has kindly agreed to let us
include in our series of case studies.
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